Test A-Z

Tests available

Test

Target turnaround

Validated Sample types

Client sample postage: returns and forwarding to PHE

Next day

Anyψ

16S rRNA bacterial gene detection

2 days

Any (inc. fixed tissue) preferably from normally sterile sites

16S rRNA bacterial gene sequencing

2 days

PCR product (see detection above) or bacterial culture

Pan fungal DNA detection

3 days

Any (inc. fixed tissue) preferably from normally sterile sites

Pan fungal DNA sequencing

3 days

PCR product (see detection above) or fungal culture

Acanthamoeba DNA

2 days

For eyes - Corneal scrape, swab or contact lens, contact lens solution

Meningitis - CSF

Adenovirus DNA

Next day

Vitreous fluid, eye fluid, serum, skin swab, blood plasma, urine, bronchial washings, NPA,swab (Nose, throat, eye), CSF, pericardial fluid, bone marrow.

Adenovirus DNA quantitation

Next day

EDTA/citrated whole blood CSF and plasma

Adenovirus typing (Research only)

5 days

PCR product generated in-house from the sample types detailed for Adenovirus DNA

Alpha-1 antitrypsin genotyping

5 days

EDTA/citrated whole blood

Aspergillus genus DNA

5 days

EDTA/citrated whole blood/ lower respiratory sample ((BAL, bronchial washings, sputum)

Bartonella genus

2 days

EDTA whole blood, tissue

Bocavirus

Next day

Any upper / lower respiratory specimen (sputum, BAL, NPA, nasopharyngeal swab etc), BAL and NPA preferred

Bordetella pertussis DNA

2 days

NPA, perinasal and nasopharyngeal swab

Borrelia genus

2 days

EDTA/citrated whole blood, CSF, skin biopsy

Brucella genus DNA

3 days

EDTA/citrated whole blood, CSF, tissue.We do not accept cultures for safety reasons

Candida albicans DNA

2 days

EDTA/citrated whole blood, CSF, eye fluid

Chlamydia pneumoniae DNA

Next day

Any respiratory specimen (sputum, BAL, NPA, nasopharyngeal swab etc), BAL and NPA preferred

Chlamydia psittaci DNA

2 days

BAL, nasopharyngeal swab

Chlamydia trachomatis DNA

If sending for confirmation in accordance with BASHH guidelines, please telephone the laboratory for further information.

2 days

Eye swab, throat swab

For genitourinary: Female: Endocervical, vaginal or rectal swab, ‘Thin prep’ endocervical cellular specimens. Male: Urethral swab, first pass urine, rectal swab

Clostridium difficile (Research only)

3 days

Stool

Coronavirus 229E, HKU1, NL63 or OC43

Next day

Any upper / lower respiratory sample

Coxiella burnetii

Next day

EDTA whole blood, BAL and tissues.We do not accept cultures for safety reasons.

Cryptococcus neoformans DNA

Next day

CSF, EDTA whole blood

Cytomegalovirus DNA

Same day

EDTA/citrated whole blood, urine, serum/EDTA plasma, eye fluid, tissue, biopsy or respiratory specimen - BAL preferred.

Pregnancy – EDTA whole blood, amniotic fluid, cervical swab, serum/plasma

Cytomegalovirus DNA quantitation

Same day

EDTA/citrated whole blood, urine, serum/EDTA plasma, eye fluid

Cytomegalovirus ganciclovir resistance

5 days

As for CMV DNA

Enterovirus RNA

Next day

CSF, swab, stool, tissue, serum, plasma, EDTA/citrated whole blood - may be useful in suspected meningitis cases

Enterovirus typing (Research only)

3 days

CSF, EDTA/citrated whole blood, stool, respiratory samples, tissue, serum, plasma

Epstein Barr Virus DNA

Same day

EDTA/citrated whole blood, CSF, urine, serum, plasma, biopsy,

Epstein Barr Virus DNA quantitation

Same day

EDTA/citrated whole blood, CSF, urine, serum, plasma

Escherichia coli DNA

2 days

CSF, EDTA/citrated whole blood

Factor V Mutation + Prothrombin

5 days

EDTA / citrated whole blood

Forensic DNA Profiling – tissue extraction

10 days

Muscle

Forensic DNA Profiling - extraction from bone or teeth

15 days

Bone/teeth

Forensic DNA Profiling

For identification of human remains and comparison of clinical samples

10 days

Cheek swab, EDTA/citrated whole blood, tissue, serum, fixed tissue (least preferred sample), personal items (Hairbrush, comb, razor)

Group A Streptococcus (S.pyogenes) DNA

Next day

CSF, EDTA/citrated whole blood, tissue

Group B Streptococcus (S. agalactiae) DNA

Next day

CSF, EDTA/citrated whole blood, tissue

Haemochromatosis H63D C282Y

5 days

EDTA / citrated whole blood

Haemophilus ducreyi DNA

2 days

Swab

Haemophilus influenzae/parainfluenzae DNA

Next day

CSF, EDTA/citrated whole blood.

HBV Core/PreCore Mutations

5 days

Serum/plasma

Hepatitis B core antibody

(Tests schedule Monday and Thursday)

3 days

Li‑heparin, Na‑heparin, K2‑EDTA, K3‑EDTA, ACD, CPD, CP2D, CPDA and Na‑citrate plasma

Hepatitis B e antibody

(Tests schedule Monday and Thursday)

3 days

Li‑heparin, Na‑heparin, K2‑EDTA, K3‑EDTA, ACD, CPD, CP2D, CPDA and Na‑citrate plasma

Hepatitis B e antigen

(Tests schedule Monday and Thursday)

3 days

Serum preferred or Na-heparin*, Li‑heparin*, K2‑EDTA, K3‑EDTA, ACD, CPD, CP2D, CPDA and Na‑citrate plasma.

Hepatitis B drug resistance mutation screen♦

5 days

Serum/plasma Please supply viral load if available.

Hepatitis B surface antibody

(Tests schedule Monday and Thursday)

3 days

Serum preferred or K2/K3EDTA plasma **

Hepatitis B surface antigen

(Tests schedule Monday and Thursday)

3 days

Serum preferred or Li-heparin*, Na-citrate, K2/K3- EDTA, CPDA, CPD, CP2D, ACD, citrate plasma.

Hepatitis B surface antigen quantitation

(Tests schedule Monday and Thursday)

3 days

Serum preferred or Li-heparin*, Na-heparin*, K2-EDTA, citrate plasma

Hepatitis B virus DNA (<10IU/mL)

Next day

At least 0.3ml serum/plasma

Hepatitis B virus DNA quantitation (<10IU/mL)

Next day

At least 0.3ml serum/plasma

Hepatitis B genotyping ♦

3 days

Serum/plasma

Hepatitis C antibody (EIA)

(Tests schedule Monday and Thursday)

3 days

serum preferred or Li-heparin*, K2/K3-EDTA, Na-heparin, Na-citrate, CPDA, CPD, CP2D, and ACD plasma.

Hepatitis C antibody (RIBA)

(Tests schedule Monday and Thursday)

3 days

Serum preferred or Li-heparin*, citrate or EDTA plasma

Hepatitis C NS3 Q80K polymorphism ♦

3 days

At least 0.3ml serum/plasma Please supply viral load if available.

Hepatitis C NS5A resistance testing ♦

4 days

At least 0.3ml serum/plasma Please supply viral load if available.

Hepatitis C genotyping ♦

3 days

Serum/plasma Please supply viral load if available.

Hepatitis C virus RNA (<15IU/ml)

Next day

At least 0.7ml serum/plasma

Hepatitis C virus RNA quantitation (<15IU/ml)

Next day

At least 0.7ml serum/plasma

Hepatitis D virus RNA ♦

3 days

Serum/plasma. This assay should always be reviewed in conjunction with HBV investigations.

Hepatitis D virus RNA quantitation ♦

3 days

Serum/plasma. This assay should always be reviewed in conjunction with HBV investigations.

Hepatitis E virus RNA

2 days

Serum/plasma, CSF, whole blood, stool

Hepatitis E virus RNA quantitation

2 days

Serum/plasma, CSF, whole blood

Herpes Simplex virus DNA ▲

Next day

CSF, AC tap, EDTA/citrated whole blood, vesicle fluid, skin/eye/corneal vesicle/lesion swab, tissue (Biopsy and fixed included).

Any respiratory specimen (sputum, BAL, NPA, nasopharyngeal swab etc) .

aqueous / vitreous humour.

Genitourinary - For female: Endocervical or vulval lesions sample area with a swab and place into viral transport media (VTM). Male: Penile lesions - Penile swab placed into VTM.Urine is not a recommended sample type for diagnosis of infection in male or females.

Pregnancy – vulval/vaginal swab

Herpes Simplex Acyclovir drug resistance

5 days

HSV-1 positive samples, including CSF, Corneal scrapes, vesicle fluid, swabs, and whole blood

Herpes Simplex virus types I & II typing ▲

Next day

Performed routinely on positive HSV samples (including CSF, amniotic fluid, EDTA/citrated-whole blood, vesicle fluid, skin/lesion swab, tissue samples and biopsies, any respiratory specimen (sputum, BAL, NPA, nasopharyngeal swab etc).

HSV positive eye samples and oral swabs are typed upon request.

Specific requirements for genitourinary samples: Males: Penile lesions-penile swabs placed into VTM. Females: Endocervical or vulval lesion swabs placed into VTM. In pregnancy, vulval/vaginal swabs placed into VTM. Urine is not a recommended sample type for the diagnosis of infection in male or female patients.

HIV I & II antibody and p24 antigen (EIA) (Tests schedule Monday and Thursday)

3 days

Serum preferred or Li-heparin*, EDTA, ACD, CPD, CP2D, CPDA and Na‑citrate plasma

HIV I & II antibody (LIA)

(Tests schedule Monday and Thursday)

3 days

Serum preferred or Li-heparin*, citrate or EDTA plasma

HIV I & II antibody (LIA) – saliva

(Tests schedule Monday and Thursday)

3 days

Saliva

HIV-1 proviral LTR, env, gag and pol genes

2 days

EDTA whole blood preferred or serum/plasma, CSF

HIV-1 RNA drug resistance ♦

9 days

Serum/plasma.This test requires at least 500μL of sample. Please supply viral load if available.

HIV-1 RNA Integrase drug resistance ♦

9 days

Serum/plasma. This test requires at least 500μL of sample. Please supply viral load if available.

HIV-1 RNA quantitation ♦

3 days

EDTA Plasma, CSF. Please supply 2mL EDTA plasma.

HIV-2 proviral LTR and pol DNA/RNA

2 days

EDTA whole blood preferred or serum/plasma, CSF

HTLV I & II antibody

(Tests scheduled Wednesday)

2 days

Serum preferred or EDTA, citrate plasma

HTLV DNA or RNA

3 days

EDTA/citrated whole blood or CSF

Human Herpesvirus 6 DNA

Next day

EDTA/citrated whole blood (CSF in encephalitis), bone marrow biopsies, , plasma, serum

Human Herpesvirus 6 DNA quantitation

Next day

EDTA/citrated whole blood (CSF in encephalitis), bone marrow, plasma, serum

Human Herpesvirus 7 DNA

Next day

EDTA/citrated whole blood, CSF, plasma***, serum***

Human Herpesvirus 8 DNA

Next day

EDTA/citrated whole blood, plasma***, serum***

Human Herpesvirus 8 DNA quantitation

Next day

EDTA/citrated whole blood, plasma***, serum***

Human metapneumovirus RNA

Same day

Any upper / lower respiratory specimen

Human Papillomavirus DNA detection

5 days

Swab, tissue (including fixed).Please state site of swab / tissue type.

For genital samples: Female: Endocervical swab sent in VTM or ‘thin prep’ endocervical cellular specimens. Male: Penile swab placed into VTM or fresh biopsy tissue.

Human Papillomavirus DNA typing

5 days

Any positive detected from samples detailed for HPV detection.

Human Papillomavirus DNA high risk typing(Genital samples only)

5 days

Female: Endocervical swab sent in VTM or ‘thin prep’ endocervical cellular specimens.

Male: Penile swab placed into VTM.

IL28B gene (rs12979860)

4 days

EDTA / citrated whole blood

Influenza A virus RNA

Same day

Any upper / lower respiratory specimen

Influenza B virus RNA

Same day

Any upper / lower respiratory specimen

Leptospira genus DNA

3 days

CSF, EDTA/citrated whole blood, urine

Lymphogranuloma venereum

4 days

Male - first catch urine, genital swab, rectal swab, throat swab, rectal biopsy/tissue, lymph node tissue/biopsy.Female - genital swab, throat swab, rectal swab, rectal biopsy/tissue, lymph node tissue/biopsy

Listeria monocytogenes DNA

Next day

CSF, EDTA/citrated whole blood - may be useful in suspected meningitis cases

Measles virus RNA

Next day

CSF, urine, saliva, mouth/throat swab, whole blood

Mumps IgG antibody

(Tests schedule Wednesday)

4 days

Serum preferred or citrate plasma

Mumps virus RNA

Next day

CSF, urine, saliva, mouth/throat swab

Mycobacterium avium complex\TB complex DNA

2 days

Sputum, tissue, fixed tissue, CSF, BAL

Mycobacterium genus DNA

4 days

Sputum, tissue, fixed tissue, CSF, BAL

Mycobacterium TB rifampicin resistance

3 days

Sputum, tissue, fixed tissue, CSF, BAL

Mycoplasma genitalium DNA

2 days

Urine/genital swab

Mycoplasma genus DNA

4 days

CSF, EDTA/citrated whole blood, tissue culture

Mycoplasma pneumoniae DNA

Next day

EDTA whole bloodand any respiratory specimen (sputum, BAL, NPA, nasopharyngeal swab etc), BAL and NPA preferred

Neisseria gonorrhoeae DNA

If sending for confirmation in accordance with BASHH guidelines, please telephone the laboratory for further information.

2 days

Eye swab

For genitourinary: Female: Endocervical, vaginal or rectal swab, ‘Thin prep’ endocervical cellular specimens.Male: Urethral swab, first pass urine, rectal swab

Neisseria meningitidis DNA

Same day

CSF, EDTA/citrated whole blood (may be useful in suspected meningitis cases)

Neisseria meningitidis DNA typing

2 days

Performed routinely on positive Neisseria meningitidis samples

Parainfluenza 1,2,3 and 4 virus RNA

Same day

Any upper / lower respiratory specimen

Parechovirus RNA

Next day

CSF, swab, stool, tissue, serum, plasma, EDTA/citrated whole blood - may be useful in suspected meningitis cases

Parvovirus B19 DNA

Next day

EDTA/citrated whole blood, amniotic fluid, serum/plasma, post-mortem samples (Foetal), CSF, bone marrow

Parvovirus B19 DNA quantitation

Next day

EDTA/citrated whole blood, amniotic fluid, serum/plasma, CSF

Paternity Testing

7 days

Cheek swab

Pneumocystis jirovecii (aka carinii) DNA

Next day

Sputum, BAL, NPA preferred.

Polyoma BK virus DNA

Next day

EDTA/citrated whole blood, urine, CSF

Polyoma BK virus DNA quantitation

Next day

EDTA/citrated whole blood, urine, CSF

Polyoma JC virus DNA

Next day

EDTA/citrated whole blood, urine, CSF

Polyoma JC virus DNA quantitation

Next day

EDTA/citrated whole blood, urine, CSF

Propionibacteria/Actinomyces DNA

2 days

Eye sample, tissue, CSF

Pseudomonas aeruginosa▲

Next day

EDTA whole blood, corneal scrape, eye swab, contact lens or contact lens solution

Respiratory Syncytial Virus RNA

Same day

Any upper / lower respiratory specimen

Respiratory Virus Screen See ʘ below

Next day

Any upper / lower respiratory specimen

Rhinovirus RNA

Same day

Any upper / lower respiratory specimen

Rhinovirus typing (Research only)

3 days

Any positive Rhinovirus respiratory specimen

Rubella virus RNA

Next day

CSF, EDTA/citrated whole blood, throat swab, urine, amniotic fluid

Salmonella enterica (Research only)

Next day

CSF, EDTA/citrated whole blood – may be useful in suspected meningitis cases, tissue, abscess fluid.

Staphylococcus genus DNA

Next day

CSF, aqueous/vitreous humour, tissue

Streptococcus pneumoniae DNA

Same day

Whole blood, CSF and pleural fluid

Toxoplasma gondii DNA

Same day

CSF, EDTA/citrated whole blood, amniotic fluid, aqueous/vitreous humours, tissue

Toxoplasma IgG antibody

(Tests schedule Monday and Thursday)

5 days

Serum preferred or Li-heparin*, K3-EDTA or citrate plasma

Treponema pallidum DNA

Next day

CSF, genital swab

Trichomonas vaginalis DNA

Next day

Genital swab

Tropheryma whippelii DNA

Next day

CSF and almost any cellular material including whole blood. PLEASE DO NOT SEND SERUM.

Ureaplasma urealyticum/parvum DNA

2 days

Urine, genital swab, respiratory (neonates)

Varicella Zoster virus DNA ▲

Next day

CSF, AC tap, EDTA/citrated whole blood, corneal scrape, vesicle fluid, skin/eye/vesicle/lesion swab, tissue (Biopsy and fixed included).

Any respiratory specimen (sputum, BAL, NPA, nasopharyngeal swab etc), aqueous / vitreous humour.

Genitourinary - For female: Endocervical or vulval lesions sample area with a swab and place into viral transport media (VTM). Male: Penile lesions - Penile swab placed into VTM

Pregnancy – vulval/vaginal swab

West Nile Fever virus RNA

Next day

CSF, EDTA whole blood

 

Key for test table

▲ Currently not UKAS accredited

♦EDTA Plasma separated within 24 hours of initial collection of blood.Ship at ambient temperature for next day delivery.

* - Li Heparin/Na heparin has inhibitory effects in PCR.Please provide an alternative sample if molecular detection of viral / bacterial / fungal targets or human genetics tests are required.

** - For the Hepatitis B surface antibody assay, if plasma treated with lithium heparin, sodium citrate, sodium fluoride or potassium oxalate is used, values obtained are 25% lower compared with serum. Additionally, lithium heparin plasma tubes containing separating gel should not be used for this test.

*** - Serum and plasma may be tested but whole blood is preferred.

ʘ- Respiratory panel comprising of Influenzae A and B, Coronavirus OC43, 229E, NL63 and HKU1, Respiratory syncytial virus A and B, Parainfluenza 1 – 4, Human metapneumovirus, Rhinovirus/Enterovirus, Adenovirus, Human Bocavirus.Please note, Influenza A positives can be differentiated between H1 and H3 subtypes.If required this can be reported.

Ψ Please note; when Measles RNA, Rubella RNA, Neisseria meningitidis DNA or Bordetella pertussis DNA are detected within a specimen, the sample will be forwarded to Public Health England to comply with their requirements.

Abbreviations used in test table

ACD – Acid citrate dextrose

BAL – Bronchioalveolar lavage

CPD – Citrate phosphate dextrose

CPDA – Citrate phosphate dextrose adenine

CP2D - Citrate phosphate double dextrose

CSF – Cerebrospinal fluid

EDTA - Ethylenediaminetetraacetic acid

Li – Lithium

Na – Sodium

NPA – Nasopharyngeal aspirate

VTM – Viral transport media